Xu M, Deng X, Zhang X, Xu H, Lin L
Institute of Clinical Pharmacology, Guangzhou College of TCM.
Hua Xi Yi Ke Da Xue Xue Bao. 1994 Dec;25(4):431-3.
In order to study the effect of Baji Zibugao (BJZBG, a medicinal plaster mainly consisting of Radix Morindae Officinalis) on the endocrine functions of hypothyroid rabbits, we determined the serum levels of thyroxine (T4), triiodothyronine (T3), cAMP, cGMP and corticosterone in three groups of rabbits: total thyroidectomized and untreated (group I), total thyroidectomized and treated with BJZBG (group II) and controls (group III). The results showed: (1) The serum level of T4 in group I and II after operation was significantly lower than that before operation (P < 0.005), and the serum level of T3 in group I was also lower than that before operation (P < 0.02), but the change of T3 in group II after operation was not significant (P > 0.05); (2) The serum cAMP level in group I after operation decreased and the cGMP level increased (P < 0.025), but the changes of cAMP and cGMP level in group II after operation were not significant (P > 0.05), (3) The change of serum corticosterone level in group I or II after operation was not remarkable (P > 0.05).
为研究巴戟紫补膏（主要由巴戟天组成的一种药膏）对甲状腺功能减退家兔内分泌功能的影响，我们测定了三组家兔的血清甲状腺素（T4）、三碘甲状腺原氨酸（T3）、环磷酸腺苷（cAMP）、环磷酸鸟苷（cGMP）和皮质酮水平：全甲状腺切除且未治疗组（I组）、全甲状腺切除并用巴戟紫补膏治疗组（II组）和对照组（III组）。结果显示：（1）I组和II组术后血清T4水平显著低于术前（P<0.005），I组血清T3水平也低于术前（P<0.02），但II组术后T3变化不显著（P>0.05）；（2）I组术后血清cAMP水平降低，cGMP水平升高（P<0.025），但II组术后cAMP和cGMP水平变化不显著（P>0.05）；（3）I组或II组术后血清皮质酮水平变化不显著（P>0.05）。
