Cohen-Abbo A, Edwards K M
Dept. of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232-2581, USA.
Infection. 1995 Jan-Feb;23(1):55-7. doi: 10.1007/BF01710060.
This report describes an 18-year-old male patient with chronic granulomatous disease who developed cutaneous nodules and multifocal osteomyelitis with the saprophytic fungus Paecilomyces varioti. After several biopsies the organism was identified. Anti-fungal susceptibility testing was performed. Combination therapy with amphotericin B and gamma-interferon followed by long-term therapy with itraconazole and gamma-interferon resulted in a clinical response.
本报告描述了一名患有慢性肉芽肿病的18岁男性患者，其感染了腐生真菌拟青霉，出现了皮肤结节和多灶性骨髓炎。经过多次活检后鉴定出该病原体。进行了抗真菌药敏试验。两性霉素B和γ干扰素联合治疗，随后用伊曲康唑和γ干扰素进行长期治疗，产生了临床反应。
