Mizuno H, Isobe J, Matsunobe S, Nakamura T, Shimizu Y, Hitomi S
Chest Disease Research Institute, Kyoto University, Japan.
Int J Artif Organs. 1994 Nov;17(11):609-15.
A new liquid-liquid blood gas exchange system was investigated using a venovenous low flow extracorporeal circuit. A 2 m2 hollow fiber dialyzer served as the interface of the blood and oxygen carrier (a 38 percent FC-43, perfluorocarbon emulsion in a buffered electrolyte solution), which was continuously recycled through a bubble oxygenator. Experiments were performed on five mongrel dogs under general anesthesia. Upon the arrest of spontaneous ventilation, the dogs' lungs were inflated with 50% oxygen gas under a positive pressure of 10 cmH2O. After 10 min of apnea the dogs' PaO2 decreased to 37 +/- 14 mmHg, and the extracorporeal circulation was started at 10 ml/min/kg b./w. At 15 min the PaO2 had risen to 80 +/- 41 mmHg and at 30 min to 121 +/- 17 mmHg. The oxygen transfer was 8.3 +/- 2.3 ml/min. The extracorporeal circulation was continued 5h, when PaO2 reached 156 +/- 90 mmHg, and PaCO2 148 +/- 43 mmHg, then stopped. Fifteen minutes later, the PaO2 had returned to 32 +/- 10 mmHg. These findings indicate that our blood gas exchange system can supply a sufficient amount of oxygen to the body under apnea with continuous positive airway pressure.
使用静脉-静脉低流量体外循环对一种新型液-液血气交换系统进行了研究。一个2平方米的中空纤维透析器作为血液与氧载体（一种38%的FC-43，即全氟碳乳剂溶解于缓冲电解质溶液中）的界面，氧载体通过鼓泡式氧合器持续循环。在全身麻醉下对5只杂种狗进行了实验。自主通气停止后，狗的肺在10 cmH2O的正压下用50%的氧气充气。呼吸暂停10分钟后，狗的动脉血氧分压（PaO2）降至37±14 mmHg，然后以10 ml/min/kg体重开始体外循环。15分钟时，PaO2升至80±41 mmHg，30分钟时升至121±17 mmHg。氧转运量为8.3±2.3 ml/min。体外循环持续5小时，此时PaO2达到156±90 mmHg，动脉血二氧化碳分压（PaCO2）为148±43 mmHg，然后停止。15分钟后，PaO2恢复至32±10 mmHg。这些结果表明，我们的血气交换系统在呼吸暂停且气道持续正压的情况下能够为身体提供足够的氧气。
