Zhu X O, McNaughton N
Department of Psychology, University of Otago, Dunedin, New Zealand.
Int J Neurosci. 1994 Nov;79(1-2):91-8. doi: 10.3109/00207459408986070.
All classical anxiolytics raise the thresholds of septal-elicited hippocampal RSA overall, but do so mostly at 7.7 Hz (130 ms). The novel anxiolytic/antidepressant buspirone shows partial similarity with classical anxiolytics on septal driving thresholds. These effects of both the classical and novel anxiolytics are unchanged by long-term administration. The present experiment tested whether the tricyclic antidepressant imipramine and the monoamine oxidase inhibitor antidepressant phenelzine share these common effects of classical and novel anxiolytics with long-term administration. Rats, implanted with septal stimulating electrodes and subicular recording electrodes, received 15 mg/kg imipramine (twice per day) and 2 mg/kg phenelzine (once per day) for 28 days. Chronic administration of imipramine mimicked the documented effects of anxiolytics while chronic administration of phenelzine produced essentially opposite effects to the effects of anxiolytics on septal driving of RSA. Since both acute and chronic administration of imipramine but not phenelzine also produce similar effects to anxiolytics on the frequency of reticular-elicited hippocampal RSA, we suggest that (1) imipramine has a separate anxiolytic action, in addition to its antidepressant action; and (2) phenelzine may have no central anxiolytic action despite its capacity to relieve somatic symptoms in atypical depression.
所有经典抗焦虑药总体上都会提高隔区诱发的海马区RSA阈值，但主要是在7.7赫兹（130毫秒）时。新型抗焦虑/抗抑郁药丁螺环酮在隔区驱动阈值方面与经典抗焦虑药表现出部分相似性。经典和新型抗焦虑药的这些作用在长期给药后均未改变。本实验测试了三环类抗抑郁药丙咪嗪和单胺氧化酶抑制剂抗抑郁药苯乙肼在长期给药时是否具有经典和新型抗焦虑药的这些共同作用。给植入了隔区刺激电极和海马下记录电极的大鼠每天两次给予15毫克/千克丙咪嗪，每天一次给予2毫克/千克苯乙肼，持续28天。丙咪嗪的长期给药模拟了抗焦虑药的已记录效应，而苯乙肼的长期给药对隔区驱动RSA的效应与抗焦虑药的效应基本相反。由于丙咪嗪的急性和长期给药而非苯乙肼的给药在网状结构诱发的海马区RSA频率上也产生了与抗焦虑药相似的效应，我们认为：（1）丙咪嗪除了具有抗抑郁作用外，还具有独立的抗焦虑作用；（2）尽管苯乙肼有缓解非典型抑郁症躯体症状的能力，但它可能没有中枢抗焦虑作用。
