Zhu X O, McNaughton N
Department of Psychology and Centre for Neuroscience, University of Otago, Dunedin, New Zealand.
Neurosci Res. 1995 Feb;21(4):311-6. doi: 10.1016/0168-0102(94)00866-e.
All anxiolytics so far tested show a common reduction in the frequency of reticular-elicited hippocampal rhythmical slow activity (RSA). Acute administration of the tricyclic antidepressant imipramine shares this effect with anxiolytics. The present experiment tested whether the MAO inhibitor antidepressant phenelzine shares this common effect of anxiolytics and imipramine on hippocampal RSA. Rats, implanted with reticular stimulating electrodes and subicular recording electrodes, received four acute doses (0.2, 2.0, 6.0 and 18 mg/kg) or one chronic dose (2 mg/kg/day for 35 days) of phenelzine. Acute administration of phenelzine failed to systematically affect RSA frequency. Chronic injections of phenelzine eventually produced a reduction in RSA frequency combined with a gradual increase in baseline RSA frequency. The absence of immediate action and the production of a chronic reduction in RSA frequency are distinct from the documented effects of anxiolytics and imipramine, whereas the increase in baseline RSA frequency is similar to imipramine. The different influence of phenelzine on RSA frequency compared with anxiolytics (including imipramine) is consistent with the different clinical profiles of these drugs.
迄今为止所测试的所有抗焦虑药均显示出网状结构诱发的海马节律性慢活动（RSA）频率普遍降低。三环类抗抑郁药丙咪嗪的急性给药与抗焦虑药有相同的效果。本实验测试了单胺氧化酶抑制剂抗抑郁药苯乙肼是否与抗焦虑药和丙咪嗪对海马RSA有相同的作用。给植入了网状刺激电极和海马下记录电极的大鼠注射四个急性剂量（0.2、2.0、6.0和18mg/kg）或一个慢性剂量（2mg/kg/天，持续35天）的苯乙肼。苯乙肼的急性给药未能系统性地影响RSA频率。苯乙肼的慢性注射最终导致RSA频率降低，并伴有基线RSA频率逐渐升高。缺乏即时作用以及产生RSA频率的慢性降低不同于抗焦虑药和丙咪嗪已记录的作用，而基线RSA频率的升高与丙咪嗪相似。与抗焦虑药（包括丙咪嗪）相比，苯乙肼对RSA频率的不同影响与这些药物不同的临床特征一致。
