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梗犬强迫性追尾行为的描述、发展及对氯米帕明治疗的反应

Description and development of compulsive tail chasing in terriers and response to clomipramine treatment.

作者信息

Moon-Fanelli A A, Dodman N H

机构信息

Department of Clinical Sciences, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.

出版信息

J Am Vet Med Assoc. 1998 Apr 15;212(8):1252-7.

PMID:9569164
Abstract

OBJECTIVE

To identify factors associated with onset and continued elicitation of tail chasing in Bull Terriers and other terriers and to determine response to treatment with clomipramine hydrochloride, a serotonin-reuptake inhibitor.

DESIGN

Prospective study.

ANIMALS

18 tail-chasing terriers (15 Bull Terriers, 1 Miniature Bull Terrier, 1 American Staffordshire Terrier, 1 Jack Russell Terrier).

PROCEDURE

5 dogs were evaluated for tail chasing by a veterinarian at the behavior clinic of the veterinary teaching hospital and 13 dogs were evaluated by the owner's local veterinarian, who confirmed the diagnosis and treated the dog. It was recommended that all dogs in the study be given clomipramine orally at a dosage of 1 to 2 mg/kg (0.5 to 0.9 mg/lb) of body weight, every 12 hours.

RESULTS

Of the 18 dogs, 15 were treated with clomipramine within the recommended dosage range, and 3 dogs required treatment at a slightly higher dosage range to control tail chasing. After 1 to 12 weeks of treatment, 9 of 12 (75%) dogs were reported to have a 75% or greater improvement (reduction) in tail chasing.

CLINICAL IMPLICATIONS

Findings of this study may aid in recognition and treatment of compulsive tail chasing. In conjunction with appropriate management changes, clomipramine administration appears to be an effective treatment for this otherwise refractory condition.

摘要

目的

确定与牛头梗及其他梗类犬只开始并持续追尾巴行为相关的因素,并确定其对血清素再摄取抑制剂盐酸氯米帕明治疗的反应。

设计

前瞻性研究。

动物

18只追尾巴的梗类犬(15只牛头梗、1只迷你牛头梗、1只美国斯塔福郡梗、1只杰克罗素梗)。

程序

5只犬由兽医教学医院行为诊所的兽医评估追尾巴情况,13只犬由主人当地的兽医评估,后者确诊并治疗犬只。建议研究中的所有犬只口服盐酸氯米帕明,剂量为每12小时1至2毫克/千克(0.5至0.9毫克/磅)体重。

结果

18只犬中,15只按推荐剂量范围接受盐酸氯米帕明治疗,3只犬需要稍高剂量范围的治疗以控制追尾巴行为。治疗1至12周后,据报告12只犬中有9只(75%)追尾巴行为改善(减少)75%或更多。

临床意义

本研究结果可能有助于认识和治疗强迫性追尾巴行为。结合适当的管理改变,给予盐酸氯米帕明似乎是治疗这种难治性病症的有效方法。

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