通过体内质子磁共振波谱对脑肿瘤进行无创性特征分析。
Non-invasive characterization of brain tumor by in-vivo proton magnetic resonance spectroscopy.
作者信息
Harada M, Tanouchi M, Nishitani H, Miyoshi H, Bandou K, Kannuki S
机构信息
Department of Radiology, School of Medicine, University of Tokushima.
出版信息
Jpn J Cancer Res. 1995 Mar;86(3):329-32. doi: 10.1111/j.1349-7006.1995.tb03059.x.
We studied the feasibility of characterizing brain tumor tissue by localized proton magnetic resonance spectroscopy (1H-MRS). Twenty-six newly diagnosed tumors were examined by in-vivo 1H-MRS. The NAA (N-acetylaspartate)/Cho (choline) ratio of Grade 2 astrocytoma was higher than that of Grade 4. The Cho/Cr (creatine and phosphocreatine) ratio of meningioma was considerably higher than that of glioma of all grades. We have experienced only two cases of ependymoma and the Cho/Cr ratios of both were lower than that of glioma. It seems likely that 1H-MRS can be used to differentiate Grade 2 from Grade 4 in most cases of astrocytoma based on the NAA/Cho ratio, though a few cases will overlap. Meningioma can be distinguished easily from glioma, and the results of our study suggest that ependymoma shows a characteristic pattern on 1H-MRS, different from those of other brain tumors.
我们研究了通过局部质子磁共振波谱（1H-MRS）对脑肿瘤组织进行特征描述的可行性。对26例新诊断的肿瘤进行了活体1H-MRS检查。二级星形细胞瘤的NAA（N-乙酰天门冬氨酸）/Cho（胆碱）比值高于四级。脑膜瘤的Cho/Cr（肌酸和磷酸肌酸）比值显著高于所有级别的胶质瘤。我们仅遇到两例室管膜瘤，两者的Cho/Cr比值均低于胶质瘤。基于NAA/Cho比值，1H-MRS似乎在大多数星形细胞瘤病例中可用于区分二级和四级，尽管有少数病例会有重叠。脑膜瘤可轻松与胶质瘤区分，我们的研究结果表明室管膜瘤在1H-MRS上呈现出与其他脑肿瘤不同的特征性模式。
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