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[前列腺内镜切除术后的凝血功能障碍]

[Coagulation disorders after endoscopic resection of the prostate].

作者信息

Benizri E, Raucoules-Aimé M, Amiel J, Toubol J, Grimaud D

机构信息

Service d'Urologie, Hôpital Pasteur, Nice.

出版信息

J Urol (Paris). 1994;100(6):299-303.

PMID:7745259
Abstract

Endoscopic resection of the prostate is a well defined surgical procedure. Nevertheless, certain coagulation disorders (hypercoagulability with risk of deep vein thrombosis, haemorrhage) can raise special problems. In patients not given heparin prophylaxis, the incidence of deep vein thrombosis is 10% in transurethral resections of the prostate (TURP). The risk is higher for cancer. Among the diagnostic tools (D-dimer assay, continuous Doppler, pulsed echo-Doppler, thermography, plethysmography, ...) ascending phlebography or pulmonary angiography in case of suspected pulmonary emboli remains the gold standard. Haemorrhage is rarely related to defribination but frequently to dilution coagulopathy favoured by high blood pressure, resorption of irrigation fluid, deficient haemostasis with loss of coagulation factors or massive transfusions. Only clinically patent coagulation disorders leading to haemorrhage should be treated. For dilution coagulopathies and diffuse intravascular coagulation, treatment is based on viro-inactive fresh plasma infusion. Aprotinine is the first choice in case of fibrinolysis.

摘要

前列腺内镜切除术是一种明确的外科手术。然而,某些凝血功能障碍(具有深静脉血栓形成、出血风险的高凝状态)可能会引发特殊问题。在未接受肝素预防的患者中,经尿道前列腺切除术(TURP)后深静脉血栓形成的发生率为10%。癌症患者的风险更高。在诊断工具(D - 二聚体检测、连续多普勒、脉冲回声多普勒、热成像、体积描记法等)中,对于疑似肺栓塞,上行静脉造影或肺血管造影仍是金标准。出血很少与纤维蛋白溶解有关,但常与稀释性凝血病有关,高血压、冲洗液吸收、凝血因子丢失导致止血不足或大量输血会加重这种情况。仅应治疗导致出血的临床明显凝血功能障碍。对于稀释性凝血病和弥散性血管内凝血,治疗基于输注病毒灭活的新鲜血浆。在纤维蛋白溶解的情况下,抑肽酶是首选。

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