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[病毒源性血管炎。发病机制及治疗意义]

[Vasculitis of viral origin. Pathogenesis and therapeutic implications].

作者信息

Genereau T, Tri N'Guyen Q, Lortholary O, Cohen P, Guillevin L

机构信息

Service de Médecine Interne, Hôpital Avicenne, Bobigny.

出版信息

J Mal Vasc. 1995;20(1):1-7.

PMID:7745353
Abstract

Some viruses are unquestionably the cause of vasculitis, by different mechanisms: circulating immune complexes, cryoglobulinemia and/or direct infection of the blood vessel. The main viruses responsible for vasculitis are hepatitis B & C viruses, cytomegalovirus, parvovirus B19 and human immunodeficiency virus. Viral vasculitis are clinically protean, most of the time similar to idiopathic vasculitis. The manifestations due to the virus itself are sometimes hidden and vasculitis may reveal the viral infection. In some cases of viral vasculitis, particularly in hepatitis virus-induced vasculitis, antiviral therapy may help in controlling the disease. A viral etiology must be considered during atypical vasculitis.

摘要

一些病毒无疑是血管炎的病因,其致病机制各不相同:循环免疫复合物、冷球蛋白血症和/或血管直接感染。引发血管炎的主要病毒是乙型和丙型肝炎病毒、巨细胞病毒、细小病毒B19和人类免疫缺陷病毒。病毒性血管炎临床表现多样,多数情况下与特发性血管炎相似。病毒本身引起的表现有时不明显,血管炎可能是病毒感染的首发症状。在某些病毒性血管炎病例中,尤其是肝炎病毒引起的血管炎,抗病毒治疗可能有助于控制病情。非典型血管炎时必须考虑病毒病因。

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