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胸膜外布比卡因用于减轻多根肋骨骨折疼痛

Extrapleural bupivacaine for amelioration of multiple rib fracture pain.

作者信息

Haenel J B, Moore F A, Moore E E, Sauaia A, Read R A, Burch J M

机构信息

Denver General Hospital, Colorado 80204-4507, USA.

出版信息

J Trauma. 1995 Jan;38(1):22-7. doi: 10.1097/00005373-199501000-00007.

Abstract

OBJECTIVE

The pain associated with multiple rib fractures can be surprisingly variable. The objective of this study was to determine the efficacy of an indwelling, percutaneously placed intercostal catheter in relieving the pain associated with multiple rib fractures.

DESIGN

Prospective nonrandomized study setting: Surgical intensive care unit in a level 1 trauma center.

SUBJECTS

Fifteen blunt chest trauma patients with a minimum of three rib fractures who had failed an intravenous patient controlled analgesia protocol.

INTERVENTIONS

Insertion of an epidural catheter within the intercostal space. Bupivacaine 0.25% with epinephrine was injected in a volume of 20 mL. Subsequent doses were limited to a total of 400 mg per 24 hours.

MEASUREMENTS AND MAIN RESULTS

Severity of injury was estimated by using the Injury Severity Score. For each patient a preinjection visual analogue scale (VAS) and incentive spirometry (IS) lung volume were determined. Fifteen minutes following injection of 0.25% bupivacaine with epinephrine the VAS and IS were repeated. The Injury Severity Score ranged from 9 to 32 (mean 19.0 +/- 1.6). Overall, mean VAS pain scores improved significantly following the initial bolus of bupivacaine (before VAS = 7.5 +/- 0.6, after VAS = 3.5 +/- 0.5, p < 0.05) and this was associated with significant increase in IS lung volumes (before IS = 0.77 +/- 0.09, after IS = 1.3 +/- 0.13, p < 0.05). No patient experienced either insertion-related or drug administration complications.

CONCLUSIONS

These results confirm that an indwelling intercostal catheter provides a continuous nerve block resulting in a simple, safe procedure that can ameliorate the pain and splinting associated with multiple rib fractures. Although we experienced no complications, additional investigation is clearly needed.

摘要

目的

与多根肋骨骨折相关的疼痛差异可能令人惊讶。本研究的目的是确定经皮放置的肋间留置导管在缓解多根肋骨骨折相关疼痛方面的疗效。

设计

前瞻性非随机研究。地点:一级创伤中心的外科重症监护病房。

受试者

15例钝性胸部创伤患者,至少有三根肋骨骨折,且静脉自控镇痛方案无效。

干预措施

在肋间间隙插入硬膜外导管。注入20毫升含肾上腺素的0.25%布比卡因。后续剂量限制为每24小时总量400毫克。

测量指标及主要结果

采用损伤严重度评分评估损伤严重程度。为每位患者测定注射前视觉模拟评分(VAS)和激励肺活量测定法(IS)肺容积。注射含肾上腺素的0.25%布比卡因15分钟后,重复测定VAS和IS。损伤严重度评分范围为9至32(平均19.0±1.6)。总体而言,布比卡因首次推注后,平均VAS疼痛评分显著改善(注射前VAS = 7.5±0.6,注射后VAS = 3.5±0.5,p < 0.05),且这与IS肺容积显著增加相关(注射前IS = 0.77±0.09,注射后IS = 1.3±0.13,p < 0.05)。没有患者出现与插入或给药相关的并发症。

结论

这些结果证实,肋间留置导管可提供持续神经阻滞,从而形成一种简单、安全的程序,可改善与多根肋骨骨折相关的疼痛和胸廓固定。尽管我们未遇到并发症,但显然仍需要进一步研究。

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