呼肠孤病毒感染的严重联合免疫缺陷小鼠细胞毒性细胞的特征：活化细胞表达自然杀伤细胞和淋巴因子激活的杀伤样活性，但无法清除感染。
Characterization of cytotoxic cells from reovirus-infected SCID mice: activated cells express natural killer- and lymphokine-activated killer-like activity but fail to clear infection.
作者信息
Taterka J, Cebra J J, Rubin D H
机构信息
Department of Medicine, Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA.
出版信息
J Virol. 1995 Jun;69(6):3910-4. doi: 10.1128/JVI.69.6.3910-3914.1995.
Abstract
Severe combined immune deficient (SCID) mice infected orally with reovirus type 1/L die of hepatitis. Leukocytes bearing the cell surface antigens Thy-1.2 and asialoGM-1 (AsGM1) accumulate in the livers of infected animals. These cells display lytic activity toward natural killer-sensitive (YAC-1) and -resistant (P815) cell lines and murine hepatoma line Hepa 1/A1. Although these cells have the capacity to lyse infected hepatoma targets, they cannot clear the virus.
摘要
口服感染1型呼肠孤病毒/L的严重联合免疫缺陷（SCID）小鼠死于肝炎。带有细胞表面抗原Thy-1.2和去唾液酸GM-1（AsGM1）的白细胞在受感染动物的肝脏中积聚。这些细胞对自然杀伤敏感（YAC-1）和抗性（P815）细胞系以及小鼠肝癌细胞系Hepa 1/A1具有裂解活性。尽管这些细胞有能力裂解受感染的肝癌靶细胞，但它们无法清除病毒。
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