凋亡作为麻疹病毒感染细胞死亡的一个原因。
Apoptosis as a cause of death in measles virus-infected cells.
作者信息
Esolen L M, Park S W, Hardwick J M, Griffin D E
机构信息
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
J Virol. 1995 Jun;69(6):3955-8. doi: 10.1128/JVI.69.6.3955-3958.1995.
Abstract
To determine the mechanism of measles virus-induced cell death, we studied the infection of Vero cells and monocytic cell lines with wild-type (Chicago-1) and vaccine (Edmonston) strains of measles virus. DNA fragmentation indicative of apoptosis was apparent by flow cytometry, agarose gel electrophoresis, and electron microscopy. Within syncytia, DNA strand breaks were demonstrated by end labeling with terminal transferase and then by visualization.
摘要
为确定麻疹病毒诱导细胞死亡的机制，我们用麻疹病毒的野生型（芝加哥-1株）和疫苗株（埃德蒙斯顿株）研究了Vero细胞和单核细胞系的感染情况。通过流式细胞术、琼脂糖凝胶电泳和电子显微镜观察发现，表明细胞凋亡的DNA片段化现象很明显。在多核巨细胞内，通过末端转移酶进行末端标记然后观察发现了DNA链断裂。
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