Schneider-Schaulies J, Dunster L M, Kobune F, Rima B, ter Meulen V
Institut für Virologie und Immunbiologie, Würzburg, Germany.
J Virol. 1995 Nov;69(11):7257-9. doi: 10.1128/JVI.69.11.7257-7259.1995.
Recently, we found that several lymphotropic wild-type isolates of measles virus (MV) did not lead to the downregulation of CD46 following infection. We hypothesized that either the site of virus isolation, e.g., throat swab versus peripheral blood mononuclear cells, or the cell type used for the isolation may exert selective pressure on a mixed population of viruses, resulting in isolates with the differential properties observed. This hypothesis has been tested by simultaneously isolating MV from a throat swab and peripheral blood mononuclear cells from a single patient by cultivation on B95 and Vero cells. We report that neither the source of MV nor the cell type used for isolation directly influenced the capacity for CD46 modulation of these MV isolates.
最近，我们发现几种嗜淋巴细胞的麻疹病毒（MV）野生型分离株在感染后不会导致CD46的下调。我们推测，要么是病毒分离的部位，例如咽拭子与外周血单个核细胞，要么是用于分离的细胞类型，可能会对混合病毒群体施加选择压力，从而产生具有所观察到的不同特性的分离株。通过在B95和Vero细胞上培养，从一名患者的咽拭子和外周血单个核细胞中同时分离MV，对这一假设进行了检验。我们报告称，MV的来源和用于分离的细胞类型均未直接影响这些MV分离株调节CD46的能力。
