唾液肽P-C可增强糖尿病GK大鼠离体灌流胰腺的胰岛素释放，并抑制胰高血糖素释放。

Salivary peptide P-C potentiates insulin release and inhibits glucagon release from isolated perfused pancreas of the diabetic GK rat.

作者信息

Nakashima N, Kimura I, Kimura M

机构信息

Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.

出版信息

Jpn J Pharmacol. 1995 Jan;67(1):15-20. doi: 10.1254/jjp.67.15.

DOI:10.1254/jjp.67.15

PMID:7745840

Abstract

We investigated the effects of the salivary peptide P-C (P-C), a saliva-derived peptide, on glucose (8.3 mM)- and arginine (10 mM)-induced insulin release and arginine (10 mM)-induced glucagon release using the perfused pancreas of spontaneously diabetic GK rats. Both its potentiating effect on insulin release and its inhibitory effect on glucagon release were concentration-dependent in diabetic GK rats. The ratio of insulin release obtained with P-C (194 nM) to that without P-C in GK rats was the same as ratio in normal Wistar rats. The ratio (0.40) of glucagon release obtained with P-C (194 nM) to that without P-C was smaller in diabetic GK rats than that (0.75) in normal Wistar rats. These results indicate that P-C inhibits arginine-induced glucagon release in diabetic GK rat pancreas more effectively than in normal Wistar rat pancreas.

摘要

我们使用自发性糖尿病GK大鼠的灌注胰腺，研究了唾液衍生肽P-C对葡萄糖（8.3 mM）和精氨酸（10 mM）诱导的胰岛素释放以及精氨酸（10 mM）诱导的胰高血糖素释放的影响。在糖尿病GK大鼠中，其对胰岛素释放的增强作用和对胰高血糖素释放的抑制作用均呈浓度依赖性。GK大鼠中使用P-C（194 nM）时获得的胰岛素释放与未使用P-C时的胰岛素释放之比，与正常Wistar大鼠中的比例相同。糖尿病GK大鼠中使用P-C（194 nM）时获得的胰高血糖素释放与未使用P-C时的胰高血糖素释放之比（0.40），低于正常Wistar大鼠中的比例（0.75）。这些结果表明，P-C在糖尿病GK大鼠胰腺中比在正常Wistar大鼠胰腺中更有效地抑制精氨酸诱导的胰高血糖素释放。