Kimura M, Nakashima N, Kimura I
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Jpn J Pharmacol. 1990 Apr;52(4):579-85. doi: 10.1254/jjp.52.579.
The effect of salivary peptide P-C, saliva-derived peptide on glucose-induced insulin release was studied using perfused rat pancreas. Salivary peptide P-C (194 nM) remarkably potentiated glucose (8.3 and 16.7 mM)-induced insulin release, whereas the same concentration suppressed arginine (10 mM)-induced glucagon release. Both effects of salivary peptide P-C occurred in a concentration-dependent manner. These findings suggest that salivary peptide P-C may modulate both the levels of insulin and glucagon in vivo.
利用灌注大鼠胰腺研究了唾液肽P-C（一种源自唾液的肽）对葡萄糖诱导的胰岛素释放的影响。唾液肽P-C（194 nM）显著增强了葡萄糖（8.3和16.7 mM）诱导的胰岛素释放，而相同浓度则抑制了精氨酸（10 mM）诱导的胰高血糖素释放。唾液肽P-C的这两种作用均呈浓度依赖性。这些发现表明，唾液肽P-C可能在体内调节胰岛素和胰高血糖素的水平。
