• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Neonatal pharmacodynamics--basic principles. II: Drug action and elimination.

作者信息

Ohning B L

出版信息

Neonatal Netw. 1995 Mar;14(2):15-9.

PMID:7746236
Abstract

The concepts of pharmacokinetics and pharmacodynamics are summarized for the clinician who cares for the neonatal patient. Six important pharmacologic principles are simplified and presented in a fashion that should facilitate recall. In this article, the final three concepts are presented: (1) the mechanisms by which drugs exert their actions, (2) the essentials of drug elimination through biotransformation (metabolism) by the liver, and (3) the essentials of drug elimination by the kidney. Also discussed are elimination half-life, clearance, and what happens when these elimination mechanisms are overwhelmed, due to either an excess of the drug or immaturity of the newborn.

摘要

相似文献

1
Neonatal pharmacodynamics--basic principles. II: Drug action and elimination.
Neonatal Netw. 1995 Mar;14(2):15-9.
2
Neonatal pharmacodynamics--basic principles. I: Drug delivery.新生儿药效学——基本原则。I：药物递送
Neonatal Netw. 1995 Mar;14(2):7-12.
3
Clinical application of pharmacokinetics for antiarrhythmic drugs.抗心律失常药物的药代动力学临床应用。
Arch Mal Coeur Vaiss. 1981 Dec;74 Spec No:65-72.
4
Determinants of variability in clearance of exogenous compounds in neonates.新生儿中外源性化合物清除率变异性的决定因素。
Verh K Acad Geneeskd Belg. 2009;71(3):141-64.
5
Drug therapy in dental practice: general principles. Part 2 - pharmacodynamic considerations.牙科实践中的药物治疗：一般原则。第2部分 - 药效学考量
Anesth Prog. 2007 Spring;54(1):19-23; quiz 24-5. doi: 10.2344/0003-3006(2007)54[19:DTIDPG]2.0.CO;2.
6
Developmental pharmacology.发育药理学
Dev Disabil Res Rev. 2010;16(3):233-8. doi: 10.1002/ddrr.122.
7
Principles of pharmacology.药理学原理
Pediatr Clin North Am. 2011 Feb;58(1):11-9, ix. doi: 10.1016/j.pcl.2010.10.005.
8
Therapeutic drug monitoring in neonates.新生儿治疗药物监测
Neonatal Netw. 1995 Mar;14(2):21-6.
9
Pharmacokinetic and pharmacodynamic principles of drug therapy in old age. Part 1.
Int J Clin Pharmacol Ther Toxicol. 1989 Jan;27(1):13-26.
10
General principles of pharmacology.
Dent Clin North Am. 1994 Oct;38(4):585-601.

引用本文的文献

1
Overview of therapeutic drug monitoring.治疗药物监测概述。
Korean J Intern Med. 2009 Mar;24(1):1-10. doi: 10.3904/kjim.2009.24.1.1.