Paulsen J S, Butters N, Sadek J R, Johnson S A, Salmon D P, Swerdlow N R, Swenson M R
University of California, San Diego School of Medicine, USA.
Neurology. 1995 May;45(5):951-6. doi: 10.1212/wnl.45.5.951.
We administered the Mattis Dementia Rating Scale (DRS) to 120 patients to evaluate the effect of dementia severity on distinct cognitive profiles. Sixty patients with Huntington's disease (HD) and 60 patients with Alzheimer's disease (AD) were separated by dementia severity into three groups: mildly demented (DRS mean total = 129), moderately demented (DRS mean total = 117), and severely demented (DRS mean total = 102). At all levels of dementia severity, HD patients demonstrated greater impairment than AD patients on the Initiation/Perseveration subscale, whereas AD patients demonstrated greater impairment than HD patients on the Memory subscale. At moderate and severe levels of dementia, HD patients demonstrated an additional impairment in constructional praxis. These profile differences were independent of dementia severity and continued to differentiate between so-called cortical and subcortical dementias in later stages of dementia severity.
我们对120名患者进行了马蒂斯痴呆评定量表（DRS）测试，以评估痴呆严重程度对不同认知特征的影响。60名亨廷顿舞蹈症（HD）患者和60名阿尔茨海默病（AD）患者按痴呆严重程度分为三组：轻度痴呆（DRS平均总分=129）、中度痴呆（DRS平均总分=117）和重度痴呆（DRS平均总分=102）。在所有痴呆严重程度水平上，HD患者在启动/持续性分量表上的受损程度均高于AD患者，而AD患者在记忆分量表上的受损程度高于HD患者。在中度和重度痴呆水平上，HD患者在结构性实践方面存在额外受损。这些特征差异与痴呆严重程度无关，并且在痴呆严重程度的后期阶段仍能区分所谓的皮质性和皮质下性痴呆。
