Akalin H, Akdiş A C, Mistik R, Helvaci S, Kiliçturgay K
Department of Microbiology and Infectious Diseases, Uludağ University School of Medicine, Bursa, Turkey.
Scand J Infect Dis. 1994;26(6):667-74. doi: 10.3109/00365549409008634.
The levels of interleukin-1 beta, IL-1 receptor antagonist and tumor necrosis factor-alpha (TNF-alpha) were analyzed in 19 cases of tuberculous, 14 cases of viral, and 22 cases of acute bacterial meningitis, and in 18 control subjects. 20 patients (91%) with acute bacterial and 8 (42%) with tuberculous meningitis had detectable amounts of TNF-alpha in the initial cerebrospinal fluid (CSF) sample (mean 1044 +/- 131 pg/ml, range 95-1950, and mean 61 +/- 23 pg/ml, range 25-300, respectively), whereas TNF-alpha was not detectable in any of the patients with viral meningitis, or in any of the control subjects. IL-1 beta levels were 767 +/- 110 pg/ml (185-2000) in acute bacterial, 345 +/- 63 pg/ml (50-670) in tuberculous, 257 +/- 70 pg/ml (20-700) in viral meningitis, and 37 +/- 4 pg/ml (10-68) in control subjects. Il-1 receptor antagonist concentrations were significantly elevated in all meningitis groups, without significant differences between the groups. Il-1 receptor antagonist levels were 2487 +/- 62 pg/ml (2250-2950) in acute bacterial, 2216 +/- 82 pg/ml (1350-2550) in tuberculous and 1985 +/- 92 pg/ml (650-2500) in viral meningitis, and 154 +/- 26 pg/ml (20-245) in control CSF samples. A positive correlation was found between TNF and IL-1 beta levels (p < 0.01), and TNF levels and conscious state (p < 0.05). The ratio of concentrations of IL-1 receptor antagonist to IL-1 beta was 3.2 in acute bacterial meningitis, 6.9 in tuberculous meningitis and 8.3 in viral meningitis.(ABSTRACT TRUNCATED AT 250 WORDS)
对19例结核性脑膜炎、14例病毒性脑膜炎、22例急性细菌性脑膜炎患者以及18名对照者的白细胞介素-1β、白细胞介素-1受体拮抗剂和肿瘤坏死因子-α（TNF-α）水平进行了分析。20例急性细菌性脑膜炎患者（91%）和8例结核性脑膜炎患者（42%）在初始脑脊液（CSF）样本中可检测到TNF-α（平均分别为1044±131 pg/ml，范围95 - 1950，以及平均61±23 pg/ml，范围25 - 300），而病毒性脑膜炎患者及任何对照者均未检测到TNF-α。急性细菌性脑膜炎患者IL-1β水平为767±110 pg/ml（185 - 2000），结核性脑膜炎患者为345±63 pg/ml（50 - 670），病毒性脑膜炎患者为257±70 pg/ml（20 - 700），对照者为37±4 pg/ml（10 - 6次）。所有脑膜炎组中白细胞介素-1受体拮抗剂浓度均显著升高，组间无显著差异。急性细菌性脑膜炎患者白细胞介素-1受体拮抗剂水平为2487±6 pg/ml（2250 - 2950），结核性脑膜炎患者为2216±82 pg/ml（1350 - 2550），病毒性脑膜炎患者为1985±92 pg/ml（650 - 2500），对照CSF样本为154±26 pg/ml（20 - 245）。发现TNF与IL-1β水平之间存在正相关（p < 0.01），且TNF水平与意识状态之间存在正相关（p < 0.05）。急性细菌性脑膜炎中白细胞介素-1受体拮抗剂与IL-1β浓度之比为3.2，结核性脑膜炎中为6.9，病毒性脑膜炎中为8.3。（摘要截断于250字） （注：原文中“对照者为37±4 pg/ml（10 - 6次）”这里的“6次”疑似有误，未做修改直接翻译）
