Glinski W, Brodecka H, Glinska-Ferenz M, Kowalski D
Department of Dermatology, Warsaw School of Medicine, Poland.
Acta Derm Venereol. 1995 Jan;75(1):9-11. doi: 10.2340/0001555575911.
Serum beta-endorphin was measured by radioimmunoassay in 25 patients with atopic dermatitis and 100 healthy subjects. The neuropeptide was found to be markedly (p < 0.001) increased in patients with atopic dermatitis (9.2 +/- 3.4 pg/ml) as compared to normal controls (6.1 +/- 1.5 pg/ml). A correlation between increased serum beta-endorphin concentration and some clinical parameters of the disease has been found. The statistically significant elevation of beta-endorphin was found in patients with widespread atopic dermatitis lesions involving more than 20% of the skin surface (11.1 +/- 3.6 pg/ml), a high disease severity score (10.7 +/- 3.7 pg/ml), and previous bronchial asthma symptoms (11.6 +/- 3.1 pg/ml). A possible explanation of increased beta-endorphin is either its generation in atopic dermatitis lesions by inflammatory cells or activation of pituitary-adrenal axis by psychoneural factors in the mechanism of chronic stress.
采用放射免疫分析法对25例特应性皮炎患者和100名健康受试者的血清β-内啡肽进行了检测。结果发现，与正常对照组（6.1±1.5 pg/ml）相比，特应性皮炎患者的这种神经肽显著升高（p<0.001）（9.2±3.4 pg/ml）。研究发现血清β-内啡肽浓度升高与该疾病的一些临床参数之间存在相关性。在皮肤病变面积超过体表20%的广泛性特应性皮炎患者（11.1±3.6 pg/ml）、疾病严重程度评分较高的患者（10.7±3.7 pg/ml）以及既往有支气管哮喘症状的患者（11.6±3.1 pg/ml）中，发现β-内啡肽有统计学意义的升高。β-内啡肽升高的一种可能解释是，它要么是由炎症细胞在特应性皮炎病变中产生，要么是在慢性应激机制中由精神神经因素激活垂体-肾上腺轴所致。
