Glinski W, Brodecka H, Glinska-Ferenz M, Kowalski D
Department of Dermatology, Warsaw School of Medicine, Poland.
Br J Dermatol. 1994 Aug;131(2):260-4. doi: 10.1111/j.1365-2133.1994.tb08502.x.
Serum beta-endorphin was quantified by radioimmunoassay in 71 patients with psoriasis vulgaris, other chronic inflammatory skin diseases with T-cell infiltrates [atopic dermatitis (n = 25), and systemic sclerosis (n = 34)], and 100 healthy subjects. The neuropeptide was found to be markedly (P < 0.001) increased in patients with psoriasis (14.4 pg/ml), atopic dermatitis (9.2 pg/ml) and systemic sclerosis (9.8 pg/ml) compared with normal controls (6.1 pg/ml). The highest values of beta-endorphin were found in patients with actively spreading plaque psoriasis (17.3 pg/ml), whereas lesion-free patients showed a reduction in neuropeptide concentration (10.2 pg/ml). The levels were much higher in patients with widespread psoriatic lesions (> 60% body surface; 16.2 pg/ml), which lasted longer than 3 months (15.8 pg/ml), whereas neither the presence of stress nor itching correlated with the serum peptide concentration. Our data suggest that beta-endorphin is produced in psoriatic lesions by inflammatory cells, rather than the increased levels being the result of activation of the pituitary-adrenal axis by chronic stress. The generation of neuropeptide in psoriatic lesions and its antinociceptive effect on the peripheral sensory nerves might explain why pruritus is a relatively rare phenomenon in psoriasis.
采用放射免疫分析法对71例寻常型银屑病患者、其他伴有T细胞浸润的慢性炎症性皮肤病患者[特应性皮炎（n = 25）和系统性硬化症（n = 34）]以及100名健康受试者的血清β-内啡肽进行了定量分析。结果发现，与正常对照组（6.1 pg/ml）相比，银屑病患者（14.4 pg/ml）、特应性皮炎患者（9.2 pg/ml）和系统性硬化症患者（9.8 pg/ml）的神经肽水平显著升高（P < 0.001）。β-内啡肽水平最高的是处于斑块进行期的银屑病患者（17.3 pg/ml），而无皮损患者的神经肽浓度则有所降低（10.2 pg/ml）。广泛银屑病皮损患者（体表面积> 60%；16.2 pg/ml）以及病程超过3个月患者（15.8 pg/ml）的β-内啡肽水平更高，而应激或瘙痒的存在与血清肽浓度均无相关性。我们的数据表明，β-内啡肽是由银屑病皮损中的炎症细胞产生的，而非慢性应激激活垂体-肾上腺轴导致其水平升高。银屑病皮损中神经肽的产生及其对外周感觉神经的镇痛作用可能解释了为什么瘙痒在银屑病中相对少见。
