Georgala S, Schulpis K H, Papaconstantinou E D, Stratigos J
A. Syngros University Hospital, Dermatologic Clinic, Athens, Greece.
J Dermatol Sci. 1994 Oct;8(2):125-8. doi: 10.1016/0923-1811(94)90006-x.
Atopic dermatitis (AD) is a pruritic cutaneous inflammatory condition. As pruritus and pain are very close symptoms, we determined the beta-endorphin serum concentrations in 21 atopic children with pruritus (group A) and 20 children with healed AD without pruritus (group B). Twenty-five healthy school children were the control group. The beta-endorphin serum concentrations (14.95 +/- 2.75 pmol/l) in group A were statistically (P < 0.001) elevated in our patients compared to controls (8.85 +/- 2.39 pmol/l) whereas these in group B were not elevated (9.4 +/- 2.46 pmol/l). We suggest that the elevated beta-endorphin concentrations in atopic patients with pruritus confirm the hypothesis that there is an increased activity of their opioid system and that an opioid antagonist might block itching which is their major clinical symptom.
特应性皮炎（AD）是一种瘙痒性皮肤炎症性疾病。由于瘙痒和疼痛是非常相似的症状，我们测定了21名有瘙痒症状的特应性儿童（A组）和20名已治愈且无瘙痒症状的AD儿童（B组）的β-内啡肽血清浓度。25名健康学童作为对照组。与对照组（8.85±2.39 pmol/l）相比，我们的患者中A组的β-内啡肽血清浓度（14.95±2.75 pmol/l）有统计学意义的升高（P<0.001），而B组则未升高（9.4±2.46 pmol/l）。我们认为，有瘙痒症状的特应性患者中β-内啡肽浓度升高证实了这样的假设，即他们的阿片系统活性增加，并且阿片拮抗剂可能会阻断作为其主要临床症状的瘙痒。
