Lahdes K K, Huupponen R K, Kaila T J
Department of Ophthalmology, University of Turku, Finland.
Acta Ophthalmol (Copenh). 1994 Dec;72(6):698-702. doi: 10.1111/j.1755-3768.1994.tb04683.x.
Ocular effects and plasma concentrations of cyclopentolate were studied in 8 volunteers after eyedrop application with two methods. While recumbent two 30 microliters drops of 1% cyclopentolate hydrochloride were instilled in randomized order either conventionally to the lower conjunctival cul-de-sac or on the inner canthus with eyes closed, followed by immediate opening of the eyes. The cycloplegic responses as well as the extent and time of maximal mydriasis did not differ significantly between the two methods. None of the parameters describing the systemic absorption of the drug differed between the treatment groups. Conventionally applied drops caused slightly longer subjective discomfort. Instilling eyedrops on the inner canthus with eyes closed is an alternative method to deliver ocular cyclopentolate with similar efficacy and safety as the conventional technique. This method could be useful especially when treating non-cooperative children.
采用两种方法对8名志愿者滴眼后环喷托酯的眼部效应和血浆浓度进行了研究。志愿者仰卧时，将两滴30微升的1%盐酸环喷托酯以随机顺序分别按常规方法滴入下结膜穹窿或闭眼滴在内眦处，随后立即睁眼。两种方法的睫状肌麻痹反应以及最大瞳孔散大的程度和时间均无显著差异。各治疗组之间描述药物全身吸收的参数均无差异。常规滴眼引起的主观不适时间略长。闭眼在内眦处滴眼药水是一种递送眼部环喷托酯的替代方法，其疗效和安全性与传统技术相似。这种方法在治疗不配合的儿童时可能特别有用。
