Richardson A, Parsons J T
Department of Microbiology, University of Virginia, Charlottesville.
Bioessays. 1995 Mar;17(3):229-36. doi: 10.1002/bies.950170309.
The integrins are receptors for proteins of the extracellular matrix, both providing a physical link to the cytoskeleton and transducing signals from the extracellular matrix. Activation of integrins leads to tyrosine and serine phosphorylation of a number of proteins, elevation of cytosolic calcium levels, cytoplasmic alkalinization, changes in phospholipid metabolism and, ultimately, changes in gene expression. The recently discovered focal adhesion kinase localizes to focal contacts, which are sites of integrin clustering, and focal adhesion kinase can physically associate with integrins in vitro. As integrins lack intrinsic catalytic activity, focal adhesion kinase is a candidate for a signaling molecule that is recruited by integrins in order to trigger the generation of intracellular second messengers. Thus, focal adhesion kinase may play a central role in signal transduction through integrins.
整合素是细胞外基质蛋白的受体，既能与细胞骨架建立物理连接，又能转导来自细胞外基质的信号。整合素的激活会导致多种蛋白质发生酪氨酸和丝氨酸磷酸化、胞质钙水平升高、细胞质碱化、磷脂代谢改变，最终导致基因表达改变。最近发现的粘着斑激酶定位于粘着斑，粘着斑是整合素聚集的部位，粘着斑激酶在体外能与整合素发生物理结合。由于整合素缺乏内在催化活性，粘着斑激酶是一种候选信号分子，可被整合素招募以触发细胞内第二信使的产生。因此，粘着斑激酶可能在通过整合素的信号转导中起核心作用。
