Miranti Cindy K, Brugge Joan S
Van Andel Research Institute, Grand Rapids, MI 49503, USA.
Nat Cell Biol. 2002 Apr;4(4):E83-90. doi: 10.1038/ncb0402-e83.
Cell adhesion mediated by integrin receptors has a critical function in organizing cells in tissues and in guiding haematopoietic cells to their sites of action. However, integrin adhesion receptors have broader functions in regulating cell behaviour through their ability to transduce bi-directional signals into and out of the cell and to engage in reciprocal interactions with other cellular receptors. This historical perspective traces the key findings that have led to our current understanding of these important functions of integrins.
由整合素受体介导的细胞黏附在组织中细胞的组织以及引导造血细胞到达其作用位点方面具有关键作用。然而，整合素黏附受体通过其将双向信号传入和传出细胞以及与其他细胞受体进行相互作用的能力，在调节细胞行为方面具有更广泛的功能。这一历史视角追溯了导致我们目前对整合素这些重要功能理解的关键发现。
