Kumar C C
Department of Tumor Biology, Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA.
Oncogene. 1998 Sep 17;17(11 Reviews):1365-73. doi: 10.1038/sj.onc.1202172.
Adhesive interactions are critical for the proliferation, survival and function of all cells. Integrin receptors as the major family of adhesion receptors have been the focus of study for more than a decade. These studies have tremendously enhanced our understanding of the integrin-mediated adhesive interactions and have unraveled novel integrin functions in cell survival mechanisms and in the activation of divergent signaling pathways. The signals from integrin receptors are integrated from those originating from growth factor receptors in order to organize the cytoskeleton, stimulate cell proliferation and rescue cells from matrix detachment-induced programmed cell death. These functions are critical in the regulation of multiple processes such as tissue development, inflammation, angiogenesis, tumor cell growth and metastasis and programmed cell death.
黏附相互作用对所有细胞的增殖、存活及功能至关重要。整合素受体作为主要的黏附受体家族，十多年来一直是研究的焦点。这些研究极大地增进了我们对整合素介导的黏附相互作用的理解，并揭示了整合素在细胞存活机制及不同信号通路激活中的新功能。整合素受体发出的信号与源自生长因子受体的信号整合在一起，以组织细胞骨架、刺激细胞增殖并使细胞免于基质脱离诱导的程序性细胞死亡。这些功能在组织发育、炎症、血管生成、肿瘤细胞生长与转移以及程序性细胞死亡等多个过程的调控中至关重要。
