Goldman D
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, DICBR, Bethesda, MD 20892, USA.
Alcohol Alcohol Suppl. 1993;2:27-9.
The cloning of the DRD2 dopamine receptor gene and discovery of an associated polymorphism permitted genetic association and linkage studies to alcoholism. Extensive allele frequency differences between populations provide an alternative explanation for explaining a DRD2 association to alcoholism which has been observed in some studies, but more frequently has not been replicated.
DRD2多巴胺受体基因的克隆以及一种相关多态性的发现，使得对酒精中毒进行基因关联和连锁研究成为可能。不同人群之间广泛的等位基因频率差异，为解释DRD2与酒精中毒之间的关联提供了另一种解释，这种关联在一些研究中已被观察到，但更常见的是未能得到重复验证。
