Hesselbrock V, Bauer L, O'Connor S, Gillen R
Department of Psychiatry, University of Connecticut School of Medicine, Farmington 06030, USA.
Alcohol Alcohol Suppl. 1993;2:95-100.
Both a family history of alcoholism (FH+) and a personal history of Antisocial Personality Disorder (ASP) increase the risk for developing alcoholism, particularly among males. Previous studies suggest that a reduced P300 event-related potential (ERP) amplitude is a marker of the presence of a family history of alcoholism. The present study examined the effects of both a FH+ and a personal history of ASP in relation to the P300 amplitude in a sample of 79 nonalcoholic young men. Reduced P300 ERP amplitudes elicited by a visual oddball task were found at the frontal electrode sites for both the FH+ and ASP groups, but not their interaction. There were no group differences in P300 latencies. P300 amplitude at Pz was associated with behavioral measures of figural memory, while P300 at F8 was associated with behavioral measures of cognitive flexibility.
酗酒家族史（FH+）和反社会人格障碍（ASP）个人史都会增加患酒精中毒的风险，尤其是在男性中。先前的研究表明，P300事件相关电位（ERP）波幅降低是酗酒家族史存在的一个标志。本研究在79名非酒精性年轻男性样本中，考察了FH+和ASP个人史与P300波幅的关系。在视觉oddball任务诱发的P300 ERP波幅中，FH+组和ASP组在额叶电极部位均出现降低，但二者不存在交互作用。P300潜伏期在各组之间没有差异。Pz点的P300波幅与图形记忆的行为测量指标相关，而F8点的P300与认知灵活性的行为测量指标相关。
