P3 事件相关脑电位的遗传力和分子遗传基础：全基因组关联研究。
Heritability and molecular-genetic basis of the P3 event-related brain potential: a genome-wide association study.
机构信息
Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
出版信息
Psychophysiology. 2014 Dec;51(12):1246-58. doi: 10.1111/psyp.12345.
Abstract
P3 amplitude is a candidate endophenotype for disinhibitory psychopathology, psychosis, and other disorders. The present study is a comprehensive analysis of the behavioral- and molecular-genetic basis of P3 amplitude and a P3 genetic factor score in a large community sample (N = 4,211) of adolescent twins and their parents, genotyped for 527,829 single nucleotide polymorphisms (SNPs). Biometric models indicated that as much as 65% of the variance in each measure was due to additive genes. All SNPs in aggregate accounted for approximately 40% to 50% of the heritable variance. However, analyses of individual SNPs did not yield any significant associations. Analyses of individual genes did not confirm previous associations between P3 amplitude and candidate genes but did yield a novel association with myelin expression factor 2 (MYEF2). Main effects of individual variants may be too small to be detected by GWAS without larger samples.
摘要
P3 波幅是去抑制性精神病理学、精神病和其他障碍的候选内表型。本研究对青少年双胞胎及其父母的大社区样本（N=4211）的 P3 波幅和 P3 遗传因素评分的行为和分子遗传基础进行了综合分析，并对其进行了基因分型，共检测了 527829 个单核苷酸多态性（SNP）。生物计量模型表明，每个测量值的方差中有多达 65%是由加性基因决定的。所有 SNP 总计约占可遗传方差的 40%至 50%。然而，对单个 SNP 的分析并没有产生任何显著的相关性。对个别基因的分析没有证实 P3 波幅与候选基因之间的先前关联，但确实与髓鞘表达因子 2（MYEF2）存在新的关联。如果没有更大的样本，单个变异的主要效应可能太小，无法通过 GWAS 检测到。
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本文引用的文献
1
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2
A genome-wide association study of behavioral disinhibition.行为抑制障碍的全基因组关联研究。
Behav Genet. 2013 Sep;43(5):363-73. doi: 10.1007/s10519-013-9606-x. Epub 2013 Aug 14.
3
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4
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