Sheth A P, Esterly N B, Ratoosh S L, Smith J P, Hebert A A, Silverman E
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Br J Dermatol. 1995 Apr;132(4):520-6. doi: 10.1111/j.1365-2133.1995.tb08705.x.
Neonatal lupus erythematosus (NLE) is an antibody-mediated disorder most commonly associated with autoantibodies to Ro and/or La antigens. There have been five previous reports describing eight NLE patients with anti-U1RNP antibody in the absence of anti-Ro and anti-La autoantibodies. We report two cases of anti-U1RNP antibody-positive NLE, and briefly review the five previous reports. The diagnosis of NLE was based on physical examination and serological studies by ELISA, immunodiffusion, and immunoblotting. By conventional immunodiffusion and ELISA, our cases were negative for anti-Ro and anti-La antibodies, and positive for anti-U1RNP antibody. However, one of the mothers had anti-La antibody detected by immunoblot assay only. All anti-U1RNP antibody-positive infants had classic cutaneous lesions of NLE, but it is of interest that none had congenital heart block (CHB). Although these infants were negative for anti-Ro and anti-La antibodies with immunodiffusion and ELISA techniques, these antibodies might be detectable by immunoblotting, as was the case in one of the mothers.
新生儿红斑狼疮（NLE）是一种抗体介导的疾病，最常见于与抗Ro和/或La抗原的自身抗体相关。此前有五篇报道描述了八例无抗Ro和抗La自身抗体情况下的抗U1RNP抗体阳性的NLE患者。我们报告两例抗U1RNP抗体阳性的NLE病例，并简要回顾此前的五篇报道。NLE的诊断基于体格检查以及通过酶联免疫吸附测定（ELISA）、免疫扩散和免疫印迹法进行的血清学研究。通过传统免疫扩散和ELISA检测，我们的病例抗Ro和抗La抗体均为阴性，抗U1RNP抗体为阳性。然而，其中一位母亲仅通过免疫印迹法检测到抗La抗体。所有抗U1RNP抗体阳性的婴儿均有NLE典型的皮肤损害，但有趣的是，无一例有先天性心脏传导阻滞（CHB）。尽管这些婴儿通过免疫扩散和ELISA技术检测抗Ro和抗La抗体为阴性，但这些抗体可能通过免疫印迹法检测到，就像其中一位母亲的情况一样。
