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The Child as a Surrogate for Diagnosis of Lupus in the Mother.儿童作为母亲狼疮诊断的替代指标
Case Rep Rheumatol. 2017;2017:8247591. doi: 10.1155/2017/8247591. Epub 2017 Mar 13.
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本文引用的文献

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Neonatal Lupus erythematosus Following Rheumatoid Arthritis: Case Report and Literature Review.类风湿关节炎后新生儿红斑狼疮：病例报告及文献综述
Iran J Pediatr. 2014 Aug;24(4):445-8. Epub 2014 May 16.
2
[Neonatal lupus syndrome: Literature review].[新生儿狼疮综合征：文献综述]
Rev Med Interne. 2015 Mar;36(3):159-66. doi: 10.1016/j.revmed.2014.07.013. Epub 2014 Sep 17.
3
Neonatal lupus syndrome in a Nigerian child.一名尼日利亚儿童的新生儿狼疮综合征。
BMJ Case Rep. 2012 May 11;2012:bcr0120125710. doi: 10.1136/bcr.01.2012.5710.
4
Congenital heart block: evidence for a pathogenic role of maternal autoantibodies.先天性心脏传导阻滞：母体自身抗体致病作用的证据。
Arthritis Res Ther. 2012 Apr 26;14(2):208. doi: 10.1186/ar3787.
5
Anti-SSA/Ro antibodies and the heart: more than complete congenital heart block? A review of electrocardiographic and myocardial abnormalities and of treatment options.抗SSA/Ro抗体与心脏：仅仅是完全性先天性心脏传导阻滞吗？心电图及心肌异常与治疗选择综述
Arthritis Res Ther. 2005;7(2):69-73. doi: 10.1186/ar1690. Epub 2005 Jan 25.
6
U1RNP positive neonatal lupus erythematosus: association with anti-La antibodies?U1RNP阳性新生儿红斑狼疮：与抗La抗体有关联吗？
Br J Dermatol. 1995 Apr;132(4):520-6. doi: 10.1111/j.1365-2133.1995.tb08705.x.

儿童作为母亲狼疮诊断的替代指标

The Child as a Surrogate for Diagnosis of Lupus in the Mother.

作者信息

Adelowo Olufemi O, Ohagwu Kenneth A, Aigbokhan Ejiehi E, Akintayo Richard O

机构信息

Rheumatology Unit, Department of Internal Medicine, Lagos State University Teaching Hospital, Ikeja, Nigeria.

Rheumatology Unit, Internal Medicine Department, Federal Medical Centre, Umuahia, Nigeria.

出版信息

Case Rep Rheumatol. 2017;2017:8247591. doi: 10.1155/2017/8247591. Epub 2017 Mar 13.

DOI:10.1155/2017/8247591
PMID:28386505
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5366761/
Abstract

Neonatal lupus erythematosus (NLE) is an acquired disease of the newborn caused by transplacental transfer of maternal anti-Ro/SSA, anti-La/SSB, and infrequently anti-U1 RNP antibodies. This is a case report of a male infant delivered via Caesarean section at 36-week gestation following detection of fetal bradycardia during routine antenatal clinic visit. The mother was seropositive for antinuclear antibody (ANA) and anti-Ro/SSA and had elevated erythrocyte sedimentation rate. The baby was positive for ANA, extractable nuclear antigen (ENA), and anti-Ro/SSA. Pediatric echocardiography was abnormal and electrocardiography confirmed complete heart block.

摘要

新生儿红斑狼疮（NLE）是一种新生儿获得性疾病，由母体抗Ro/SSA、抗La/SSB抗体经胎盘转移引起，抗U1 RNP抗体则较少见。这是一例病例报告，一名男婴在常规产前检查时因检测到胎儿心动过缓，于孕36周时剖宫产娩出。母亲抗核抗体（ANA）和抗Ro/SSA血清学阳性，红细胞沉降率升高。婴儿ANA、可提取核抗原（ENA）和抗Ro/SSA阳性。儿科超声心动图检查异常，心电图确诊为完全性心脏传导阻滞。