Szelke M, Evans D M, Jones D M, Fawcett L, Ashworth D, Olsson H, Featherstone R L, Church M K
Ferring Research Institute, University of Southampton Research Centre, Chilworth, UK.
Braz J Med Biol Res. 1994 Aug;27(8):1943-7.
We have recently developed synthetic low molecular weight inhibitors of both tissue and plasma kallikreins. Several of these were evaluated in vivo in the ovalbumin-sensitised guinea pig for their ability to prevent the bronchoconstriction elicited by antigen challenge. The selective tissue kallikrein inhibitor CH-694 (but not the selective plasma kallikrein inhibitor CH-684) caused highly significant falls in airways resistance when it was administered at 10 mg/kg intraperitoneally 15 min before and 90 min after challenge. There was also a highly significant fall in the tissue kallikrein activity measured in broncho-alveolar lavage fluid. Inhibitors of tissue kallikrein may prove effective in the treatment of allergic inflammation in man.
