Ryan M, Miller E, Waight P
Commun Dis Rep CDR Rev. 1995 Apr 28;5(5):R74-6.
Cytomegalovirus causes illness through primary infection but also remains latent within the host and may be reactivated, especially if immunity is impaired. We have examined reports of cytomegalovirus infection from laboratories in England and Wales received by the PHLS Communicable Disease Surveillance Centre in 1992 and 1993. A total of 2938 reports were received, and 103 people had recurrent infections within the study period. The age distribution had peaks in infants (< 1 year of age) and in people aged 25 to 34 years. In almost a half of the patients (1371; 49%) factors were reported that indicated impaired immunity. Eighty-three of the 103 with recurrent infection (81%) were also reported to have impaired immunity. Children under 5 years accounted for 18% (543/2938) of reports. There were 930 reports of infections in people over 5 years of age who were not reported as immunocompromised. The data presented confirm that cytomegalovirus causes substantial morbidity in young children and people with impaired immunity. Cytomegalovirus infection causes considerable morbidity, especially hepatic, in patients whose immunity is thought to be normal.
巨细胞病毒通过初次感染引发疾病，但也会在宿主体内潜伏，并可能被重新激活，尤其是在免疫力受损时。我们研究了1992年和1993年英国公共卫生实验室服务中心传染病监测中心收到的来自英格兰和威尔士实验室的巨细胞病毒感染报告。共收到2938份报告，103人在研究期间出现复发性感染。年龄分布在婴儿（<1岁）和25至34岁人群中出现高峰。几乎一半的患者（1371例；49%）报告了表明免疫力受损的因素。103例复发性感染患者中有83例（81%）也报告有免疫力受损。5岁以下儿童占报告的18%（543/2938）。有930份报告涉及5岁以上未报告免疫功能低下的人群感染情况。所呈现的数据证实，巨细胞病毒在幼儿和免疫力受损人群中导致大量发病。在被认为免疫功能正常的患者中，巨细胞病毒感染会导致相当大的发病率，尤其是肝脏方面的发病率。
