Walton N Y, Rubinstein B K, Treiman D M
Neurology and Research Service, Department of Veterans Affairs Medical Center, West Los Angeles, CA, USA.
Epilepsy Res. 1995 Feb;20(2):121-4. doi: 10.1016/0920-1211(94)00074-7.
Status epilepticus was induced in rats by sequential injections of lithium and pilocarpine. Seizure activity was aborted by a combination of MK-801 and diazepam, with status duration ranging from 3 to 180 min. When the hearts were examined 8-12 days later, rats that had experienced an episode of status epilepticus had significantly heavier hearts than did controls. The nature of the cardiac tissue changes was not examined, and deserves further study.
通过依次注射锂盐和毛果芸香碱在大鼠中诱发癫痫持续状态。癫痫发作活动通过MK - 801和地西泮的联合使用而终止，发作持续时间为3至180分钟。8 - 12天后检查心脏时，经历过癫痫持续状态发作的大鼠心脏明显比对照组重。心脏组织变化的性质未进行检查，值得进一步研究。
