使用CRI-MAP、并行虚拟机（PVM）以及分布式工作站网络进行遗传似然性的并行计算。

Parallel computation of genetic likelihoods using CRI-MAP, PVM, and a network of distributed workstations.

作者信息

Matise T C, Schroeder M D, Chiarulli D M, Weeks D E

机构信息

Department of Human Genetics, University of Pittsburgh, Pa 15261, USA.

出版信息

Hum Hered. 1995 Mar-Apr;45(2):103-16. doi: 10.1159/000154268.

DOI:10.1159/000154268

PMID:7750973

Abstract

We have developed a version of the CRI-MAP computer program for genetic likelihood computations that runs the FLIPS and ALL functions of CRI-MAP in parallel on a distributed network of workstations. The performance of CRI-MAP-PVM was assessed in several linkage analyses using the FLIPS option of CRI-MAP on a map of 85 microsatellite markers for human chromosome 1. These analyses showed excellent speedup and efficiency and low distribution overhead. In addition, we have adapted the MultiMap program for automated construction of linkage maps to use CRI-MAP-PVM. These improvements significantly reduce the time required to compare likelihoods of different marker orders. Thus, the construction of linkage maps can proceed in a more timely fashion, in keeping with recent advances in genotyping technology.

摘要

我们已经开发了一个用于遗传似然性计算的CRI-MAP计算机程序版本，该版本可在分布式工作站网络上并行运行CRI-MAP的FLIPS和ALL功能。在使用CRI-MAP的FLIPS选项对人类1号染色体的85个微卫星标记图谱进行的几次连锁分析中，评估了CRI-MAP-PVM的性能。这些分析显示出优异的加速比和效率以及较低的分布式开销。此外，我们已将用于自动构建连锁图谱的MultiMap程序进行了调整，以使用CRI-MAP-PVM。这些改进显著减少了比较不同标记顺序似然性所需的时间。因此，连锁图谱的构建可以更及时地进行，这与基因分型技术的最新进展相一致。