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来自紫色链霉菌的核苷酸序列及基因表达，这些基因可使加利利链霉菌产生新的蒽环类抗生素。

Nucleotide sequences and expression of genes from Streptomyces purpurascens that cause the production of new anthracyclines in Streptomyces galilaeus.

作者信息

Niemi J, Mäntsälä P

机构信息

Department of Biochemistry and Food Chemistry, University of Turku, Finland.

出版信息

J Bacteriol. 1995 May;177(10):2942-5. doi: 10.1128/jb.177.10.2942-2945.1995.

DOI:10.1128/jb.177.10.2942-2945.1995
PMID:7751313
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC176975/
Abstract

Six open reading frames, rdmA to rdmF, in a 6,077-bp segment of Streptomyces purpurascens DNA which caused the production of hybrid anthracyclines were identified. The minimal fragment that produced anthracyclines modified at the 10th position contained rdmB to rdmD; rdmE is the gene for aklavinone-11-hydroxylase. RdmC is similar to a putative open reading frame in the daunorubicin biosynthetic cluster of Streptomyces peucetius and is likely to participate in the removal of the side chain at the 10th position.

摘要

在紫色链霉菌DNA的一个6077 bp片段中鉴定出六个开放阅读框，即rdmA至rdmF，它们导致了杂合蒽环类抗生素的产生。产生第10位修饰的蒽环类抗生素的最小片段包含rdmB至rdmD；rdmE是阿克拉维酮-11-羟化酶的基因。RdmC与产紫链霉菌柔红霉素生物合成簇中的一个假定开放阅读框相似，可能参与第10位侧链的去除。

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Nucleotide sequences and expression of genes from Streptomyces purpurascens that cause the production of new anthracyclines in Streptomyces galilaeus.来自紫色链霉菌的核苷酸序列及基因表达，这些基因可使加利利链霉菌产生新的蒽环类抗生素。
J Bacteriol. 1995 May;177(10):2942-5. doi: 10.1128/jb.177.10.2942-2945.1995.
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本文引用的文献

1
Cloning and sequencing of a gene encoding carminomycin 4-O-methyltransferase from Streptomyces peucetius and its expression in Escherichia coli.来自产红链霉菌的一种编码洋红霉素4-O-甲基转移酶的基因的克隆、测序及其在大肠杆菌中的表达。
J Bacteriol. 1993 Jun;175(12):3900-4. doi: 10.1128/jb.175.12.3900-3904.1993.
2
Cloning and sequence analysis of an esterase gene from Pseudomonas sp. KWI-56.来自假单胞菌属KWI-56的酯酶基因的克隆与序列分析
Biochim Biophys Acta. 1993 Jul 18;1174(1):79-82. doi: 10.1016/0167-4781(93)90095-u.
3
Polyketide synthesis: prospects for hybrid antibiotics.聚酮化合物的合成：杂合抗生素的前景
Annu Rev Microbiol. 1993;47:875-912. doi: 10.1146/annurev.mi.47.100193.004303.
4
Cloning, sequencing, and expression of the gene encoding methylmalonyl-coenzyme A mutase from Streptomyces cinnamonensis.肉桂链霉菌甲基丙二酰辅酶A变位酶编码基因的克隆、测序及表达
J Bacteriol. 1993 Jun;175(11):3511-9. doi: 10.1128/jb.175.11.3511-3519.1993.
5
Hybrid anthracycline antibiotics: production of new anthracyclines by cloned genes from Streptomyces purpurascens in Streptomyces galilaeus.杂合蒽环类抗生素：通过来自紫色链霉菌的克隆基因在加利利链霉菌中生产新的蒽环类抗生素。
Microbiology (Reading). 1994 Jun;140 ( Pt 6):1351-8. doi: 10.1099/00221287-140-6-1351.
6
A cDNA differentially expressed between embryogenic and nonembryogenic carrot (Daucus carota L.) cells.一种在胚性和非胚性胡萝卜（胡萝卜属）细胞之间差异表达的cDNA。
Plant Physiol. 1993 Nov;103(3):1021. doi: 10.1104/pp.103.3.1021.
7
TRACTOR, a program to locate subclones in a nucleotide sequence using only one sequencing reaction.TRACTOR，一个仅使用一次测序反应就能在核苷酸序列中定位亚克隆的程序。
Comput Appl Biosci. 1994 Sep;10(5):563-6. doi: 10.1093/bioinformatics/10.5.563.
8
Chemical modification of anthracycline antibiotics. I. Demethoxycarbonylation, 10-epimerization and 4-o-methylation of aclacinomycin A.蒽环类抗生素的化学修饰。I. 阿克拉霉素A的脱甲氧羰基化、10-差向异构化和4-O-甲基化
J Antibiot (Tokyo). 1980 Nov;33(11):1323-30. doi: 10.7164/antibiotics.33.1323.
9
Lambda replacement vectors carrying polylinker sequences.携带多克隆位点序列的λ置换载体。
J Mol Biol. 1983 Nov 15;170(4):827-42. doi: 10.1016/s0022-2836(83)80190-9.
10
The relationship between base composition and codon usage in bacterial genes and its use for the simple and reliable identification of protein-coding sequences.细菌基因中碱基组成与密码子使用之间的关系及其在蛋白质编码序列简单可靠鉴定中的应用。
Gene. 1984 Oct;30(1-3):157-66. doi: 10.1016/0378-1119(84)90116-1.