LeVeen H H, Wapnick S, Piccone V, Falk G
JAMA. 1976 May 17;235(20):2198-200.
Tumor blood flow, measured by an isotope dilution technique, is only 2% to 15% of that of the surrounding tissue. This sluggish circulation differentiates cancer from normal tissue and forms the basis for a new therapy that entails the transfer of radiofrequency (RF) energy for heating tissues locally. The heated tissue is cooled by the circulation of blood, which carries away the heat. Impaired perfusion, as in cancers, impedes cooling. Heating by RF elevated the temperatures of animal and human cancers by 5 to 9.5 C above that of healthy tissue. The heat eradicated the animal cancers without destruction of normal tissue. Radiofrequency therapy produced tissue necrosis or substantial regression of cancer in 21 patients.
通过同位素稀释技术测量，肿瘤血流量仅为周围组织的2%至15%。这种缓慢的循环将癌症与正常组织区分开来，并构成了一种新疗法的基础，该疗法需要传输射频（RF）能量以局部加热组织。被加热的组织通过带走热量的血液循环来冷却。像癌症中那样的灌注受损会阻碍冷却。射频加热使动物和人类癌症的温度比健康组织高出5至9.5摄氏度。这种热量根除了动物癌症，而未破坏正常组织。射频疗法使21名患者的癌症出现组织坏死或显著消退。
