Kuliczkowski K, Darley R L, Jacobs A, Padua R A, Hoy T G
Department of Haematology, UWMC, Heath Park, Cardiff, U.K.
Leuk Res. 1995 Apr;19(4):291-6. doi: 10.1016/0145-2126(94)00161-3.
The role of p21 RAS in the proliferation and differentiation of myeloid cells has been studied by analysing the changes in the level of expression of p21 RAS proteins by flow cytometry upon differentiation down the granulocytic and monocytic pathways. Differentiation resulted in upregulated p21 RAS expression despite a marked decline in the number of dividing cells. On the other hand, growth inhibition, without differentiation, resulted in a decline in expression. Cell cycle analysis showed that the increase in p21 RAS occurred throughout the cell cycle. These results suggest that p21 RAS has a role in the process of myeloid differentiation.
通过流式细胞术分析粒细胞和单核细胞途径分化时p21 RAS蛋白表达水平的变化，研究了p21 RAS在髓细胞增殖和分化中的作用。尽管分裂细胞数量显著减少，但分化导致p21 RAS表达上调。另一方面，无分化的生长抑制导致表达下降。细胞周期分析表明，p21 RAS的增加发生在整个细胞周期。这些结果表明p21 RAS在髓细胞分化过程中起作用。
