Grosso L E, Pitot H C
Cancer Lett. 1984 Feb;22(1):55-63. doi: 10.1016/0304-3835(84)90043-0.
A cell line partially resistant to dimethylsulfoxide (DMSO) was derived from the HL-60 cell line. Cycloleucine, theophylline, sodium butyrate and elevated levels of DMSO were found to induce myeloid differentiation in this cell line while TPA induced monocytic differentiation. The levels of myc RNA and the genomic structure of the c-myc proto-oncogene were found to be the same in HL-60 and the resistant cell line. Differentiation of the DMSO resistant line was accompanied by a reduction in myc RNA levels.
一种对二甲基亚砜（DMSO）具有部分抗性的细胞系源自HL - 60细胞系。发现环亮氨酸、茶碱、丁酸钠以及较高浓度的DMSO可诱导该细胞系发生髓系分化，而佛波酯（TPA）则诱导单核细胞分化。在HL - 60细胞系和抗性细胞系中，myc RNA水平以及c - myc原癌基因的基因组结构相同。DMSO抗性细胞系的分化伴随着myc RNA水平的降低。
