Folkers K, Moesgaard S, Morita M
Institute for Biomedical Research, University of Texas at Austin, USA.
Mol Aspects Med. 1994;15 Suppl:s281-5. doi: 10.1016/0098-2997(94)90039-6.
Twenty-one healthy subjects received oral Coenzyme Q10 supplementation in soft capsules of 30 mg t.i.d. for 9 months, followed by a withdrawal period of 3 months. Blood samples were taken before start of supplementation, after 3 and 9 months of supplementation, and finally 3 months after withdrawal. Average blood coenzyme Q10 concentration increased from about 1 mg/l before supplementation to about 2 mg/l after 3 and 9 months of supplementation, and returned to the pretreatment level after withdrawal. The rise of coenzyme Q10 concentration was statistically significant (P < 0.001, t-test).
21名健康受试者口服30毫克辅酶Q10软胶囊，每日三次，持续9个月，随后有3个月的停药期。在补充开始前、补充3个月和9个月后以及停药最后3个月后采集血样。补充前平均血辅酶Q10浓度约为1毫克/升，补充3个月和9个月后升至约2毫克/升，停药后恢复到治疗前水平。辅酶Q10浓度的升高具有统计学意义（P<0.001，t检验）。
