Weis M, Mortensen S A, Rassing M R, Møller-Sonnergaard J, Poulsen G, Rasmussen S N
Royal Danish School of Pharmacy, Department of Pharmaceutics, Denmark.
Mol Aspects Med. 1994;15 Suppl:s273-80. doi: 10.1016/0098-2997(94)90038-8.
The bioavailability of four different Coenzyme Q10 (CoQ) formulations was compared in ten healthy volunteers in a four-way randomised cross-over trial. The included formulations were: A hard gelatin capsule containing 100 mg of CoQ and 400 mg of Emcompress. Three soft gelatin capsules containing: 100 mg of CoQ with 400 mg of soy bean oil (Bioquinon); 100 mg of CoQ with 20 mg of polysorbate 80, 100 mg of lecithin and 280 mg of soy bean oil; and 100 mg of CoQ with 20 mg of polysorbate 80 and 380 mg of soy bean oil, respectively. The result suggests that the soya bean oil suspension of CoQ (Bioquinon has the highest bioavailability. A difference in basic AUC and AUC after p.o. administration of CoQ was observed with respect to sex. A characteristic two peak-pattern was observed at the concentration-time profile.
在一项四向随机交叉试验中，对10名健康志愿者比较了四种不同辅酶Q10（CoQ）制剂的生物利用度。纳入的制剂有：一粒含100毫克CoQ和400毫克Emcompress的硬明胶胶囊。三粒软胶囊分别含有：100毫克CoQ与400毫克大豆油（Bioquinon）；100毫克CoQ与20毫克聚山梨酯80、100毫克卵磷脂和280毫克大豆油；以及100毫克CoQ与20毫克聚山梨酯80和380毫克大豆油。结果表明，CoQ的大豆油混悬液（Bioquinon）具有最高的生物利用度。口服CoQ后，观察到基础AUC和AUC在性别方面存在差异。在浓度-时间曲线上观察到特征性的双峰模式。
