Spangenberger H, Nikmanesh F G, Igelmund P
Zentrum Physiologie und Pathophysiologie, Universität zu Köln, Germany.
Neurosci Lett. 1995 Feb 13;185(3):217-9. doi: 10.1016/0304-3940(95)11262-u.
The effects of adenosine on synaptic transmission were studied with extracellular recordings of stimulus-induced population action potentials in area CA1 of hippocampal slices prepared from hibernating (HH) and warm-acclimated Turkish hamsters (WH) and rats. In HH as well as WH and rat slices, adenosine generally reduced the population spike amplitude and the slope of the field EPSP. The sensitivity for adenosine was significantly lower in HH slices than in WH and rat slices. The results are discussed with regard to the involvement of endogenous adenosine in the regulation of neuronal activity during entrance into and arousal from hibernation.
利用细胞外记录技术，研究了腺苷对从冬眠（HH）和暖适应土耳其仓鼠（WH）以及大鼠制备的海马切片CA1区刺激诱导的群体动作电位的突触传递的影响。在HH以及WH和大鼠切片中，腺苷通常会降低群体峰电位幅度和场兴奋性突触后电位（fEPSP）的斜率。HH切片对腺苷的敏感性显著低于WH和大鼠切片。结合内源性腺苷在进入冬眠和从冬眠中苏醒过程中对神经元活动调节的作用，对结果进行了讨论。
