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Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas.

作者信息

Singh R K, Gutman M, Bucana C D, Sanchez R, Llansa N, Fidler I J

机构信息

Department of Cell Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.

出版信息

Proc Natl Acad Sci U S A. 1995 May 9;92(10):4562-6. doi: 10.1073/pnas.92.10.4562.

DOI:10.1073/pnas.92.10.4562
PMID:7753843
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC41984/
Abstract

We investigated the influence of interferons alpha, beta, and gamma (IFN-alpha, -beta, and -gamma) on the production of basic fibroblast growth factor (bFGF) by human renal carcinoma cells. The human renal carcinoma cell metastatic line SN12PM6 was established in culture from a lung metastasis and SN12PM6-resistant cells were selected in vitro for resistance to the antiproliferative effects of IFN-alpha or IFN-beta. IFN-alpha and IFN-beta, but not IFN-gamma, down-regulated the expression of bFGF at the mRNA and protein levels by a mechanism independent of their antiproliferative effects. Down-regulation of bFGF required a long exposure (> 4 days) of cells to low concentrations (> 10 units/ml) of IFN-alpha or IFN-beta. The withdrawal of IFN-alpha or IFN-beta from the medium permitted SN12PM6-resistant cells to resume production of bFGF. The incubation of human bladder, prostate, colon, and breast carcinoma cells with noncytostatic concentrations of IFN-alpha or IFN-beta also produced down-regulation of bFGF production.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a05d/41984/1b04aa4f3491/pnas01486-0501-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a05d/41984/985d981904a6/pnas01486-0499-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a05d/41984/64064ae245f5/pnas01486-0500-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a05d/41984/aeab0b5638fc/pnas01486-0501-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a05d/41984/1b04aa4f3491/pnas01486-0501-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a05d/41984/985d981904a6/pnas01486-0499-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a05d/41984/64064ae245f5/pnas01486-0500-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a05d/41984/aeab0b5638fc/pnas01486-0501-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a05d/41984/1b04aa4f3491/pnas01486-0501-b.jpg

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