Rogers P J, Burley V J, Alikhanizadeh L A, Blundell J E
Consumer Sciences Department, Institute of Food Research, Reading, United Kingdom.
Physiol Behav. 1995 Mar;57(3):489-93. doi: 10.1016/0031-9384(94)00289-h.
Aspartame administered in capsules (i.e., without tasting) 1 h before a meal significantly reduces the amount eaten in that meal. In the present study 36 young men and women were divided into 3 groups of 12 to receive aspartame (400 mg) or placebo (400 mg starch) on separate occasions either 5 min (Group A), 30 min (Group B) or 60 min (Group C) before beginning an ad lib test meal. Compared with placebo, aspartame reduced food intake in Group C (by 18.5%, p < 0.01), but did not reliably affect intake in Groups A or B. There were, in contrast, no significant effects of aspartame on premeal ratings of hunger, desire to eat or fullness for any of the groups. These results confirm a postingestive inhibitory action of aspartame on appetite, which may involve the amplification of the satiating effects of food. The lack of effect of aspartame administered at the shorter intervals before eating suggests a postgastric or even postabsorptive mechanism of action. This observation is also important in its implications for the possible therapeutic exploitation of the anorexic effect of capsulated aspartame.
餐前1小时服用胶囊形式的阿斯巴甜（即不品尝）可显著减少该餐的进食量。在本研究中，36名年轻男女被分为3组，每组12人，在随意进食测试餐开始前，分别在5分钟（A组）、30分钟（B组）或60分钟（C组）服用阿斯巴甜（400毫克）或安慰剂（400毫克淀粉）。与安慰剂相比，阿斯巴甜降低了C组的食物摄入量（降低了18.5%，p<0.01），但对A组或B组的摄入量没有可靠影响。相比之下，阿斯巴甜对任何一组的餐前饥饿评分、进食欲望或饱腹感均无显著影响。这些结果证实了阿斯巴甜对食欲的餐后抑制作用，这可能涉及增强食物的饱腹感。在进食前较短时间内服用阿斯巴甜没有效果，这表明其作用机制可能是胃后甚至吸收后机制。这一观察结果对于胶囊形式阿斯巴甜的厌食作用的可能治疗应用也具有重要意义。
