Thompson K C, Todorovict R A, Hidalgo R J
Res Vet Sci. 1978 Mar;24(2):234-7.
Four Babesia bigemina stabilates were used to determine the immune response of cattle to acute and chronic blood- and tick-borne infections. Thirty-two intact calves were divided into 16 groups of two and each calf was inoculated with infective B bigemina erythrocytic stabilates. Twenty-eight days later they were challanged with homologous and heterologous stabilates, and monitored for an additional 20 days. The hosts' apparently reduced response to homologous challenge but marked immune response to heterologous challenge indicated antigenic differences between the isolates and confirmed the conclusions reached by examination of the serological data.
使用四种双芽巴贝斯虫稳定株来确定牛对急性和慢性血液传播及蜱传播感染的免疫反应。32头未阉割的小牛被分成16组，每组两头，每头小牛接种感染性双芽巴贝斯虫红细胞稳定株。28天后，用同源和异源稳定株对它们进行攻击，并额外监测20天。宿主对同源攻击的反应明显降低，但对异源攻击有明显的免疫反应，这表明分离株之间存在抗原差异，并证实了通过检查血清学数据得出的结论。
