Dong J T, Lamb P W, Rinker-Schaeffer C W, Vukanovic J, Ichikawa T, Isaacs J T, Barrett J C
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA.
Science. 1995 May 12;268(5212):884-6. doi: 10.1126/science.7754374.
A gene from human chromosome 11p11.2 was isolated and was shown to suppress metastasis when introduced into rat AT6.1 prostate cancer cells. Expression of this gene, designated KAI1, was reduced in human cell lines derived from metastatic prostate tumors. KAI1 specifies a protein of 267 amino acids, with four hydrophobic and presumably transmembrane domains and one large extracellular hydrophilic domain with three potential N-glycosylation sites. KAI1 is evolutionarily conserved, is expressed in many human tissues, and encodes a member of a structurally distinct family of leukocyte surface glycoproteins. Decreased expression of this gene may be involved in the malignant progression of prostate and other cancers.
从人类11号染色体p11.2分离出一个基因，当将其导入大鼠AT6.1前列腺癌细胞时，该基因显示出抑制转移的作用。这个名为KAI1的基因在源自转移性前列腺肿瘤的人类细胞系中表达降低。KAI1编码一种含267个氨基酸的蛋白质，有四个疏水且可能为跨膜的结构域以及一个大的细胞外亲水结构域，带有三个潜在的N - 糖基化位点。KAI1在进化上是保守的，在许多人类组织中表达，并编码白细胞表面糖蛋白结构上不同家族的一个成员。该基因表达降低可能参与前列腺癌和其他癌症的恶性进展。
