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局部进展期胃癌的多脏器切除术

Multi-visceral resection for locally advanced gastric cancer.

作者信息

Bloechle C, Izbicki J R, Limmer J, Kühn R, Hosch S B, Busch C, Rogiers X, Broelsch C E

机构信息

Department of Surgery, University Hospital Eppendorf, University of Hamburg, Germany.

出版信息

Acta Chir Belg. 1995 Mar-Apr;95(2):72-5.

PMID:7754735
Abstract

Fifty-three of sixty-four patients who underwent gastrectomy for gastric carcinoma presented with advanced gastric cancer. 8 patients underwent palliative gastrectomy. In 17 patients gastrectomy and lymphadenectomy was performed. In 28 patients with locally advanced gastric carcinoma, extended resection was performed. Patients who underwent splenectomy were only included if tumorous adherence to the spleen was present. Hospital mortality and morbidity were 3.6% and 25% in extended resection and 5.9% and 18% in gastrectomy and lymphadenectomy alone. R0 resection was performed in 26/28 and in 16/17 patients, respectively. In R0 (complete) resections the mean one and two-year-survival rates were 64% and 44% in extended resection, and 67% and 47% in gastrectomy and lymphadenectomy. In patients (11) with residual tumour (R1/R2) mean one and two-year-survival rates were 27% and 0%, respectively. If complete resection (R0) is achieved, extended resection for locally advanced gastric carcinoma provides survival time, which is comparable, stage for stage, with survival rates observed after R0 resection for cancer limited to the stomach.

摘要

64例因胃癌接受胃切除术的患者中,53例为进展期胃癌。8例行姑息性胃切除术。17例行胃切除术及淋巴结清扫术。28例局部进展期胃癌患者行扩大切除术。仅当肿瘤侵犯脾脏时才纳入行脾切除术的患者。扩大切除术患者的医院死亡率和发病率分别为3.6%和25%,单纯胃切除术及淋巴结清扫术患者分别为5.9%和18%。扩大切除术26/28例、胃切除术及淋巴结清扫术16/17例患者实现了R0切除。在R0(根治性)切除中,扩大切除术患者的1年和2年生存率分别为64%和44%,胃切除术及淋巴结清扫术患者分别为67%和47%。有残留肿瘤(R1/R2)的患者(11例),其1年和2年生存率分别为27%和0%。如果实现了根治性切除(R0),局部进展期胃癌的扩大切除术所提供的生存时间,在分期上与局限于胃的癌症行R0切除后的生存率相当。

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