Rinne J O, Burn D J, Mathias C J, Quinn N P, Marsden C D, Brooks D J
Medical Research Council Cyclotron Unit, Hammersmith Hospital, London, England.
Ann Neurol. 1995 May;37(5):568-73. doi: 10.1002/ana.410370505.
Ten patients with sporadic olivopontocerebellar atrophy and autonomic failure were studied with positron emission tomography. Subjects underwent both an [11C]diprenorphine and an [18F]fluorodopa scan. The mean caudate-occipital uptake ratio for [11C]diprenorphine was significantly reduced to 88% and the putamen-occipital uptake ratio to 85% of the control values. Individually, 4 of the 10 patients had significantly reduced opioid binding in the putamen. Mean putamen [18F]fluorodopa uptake was significantly diminished (to 71% of the control mean); individually 7 patients had significantly reduced uptake. There was a significant positive correlation between putamen-occipital uptake ratios for [11C]diprenorphine and putamen uptake of [18F]fluorodopa. Our results suggest that subclinical nigrostriatal dysfunction is present in the majority of patients with sporadic olivopontocerebellar atrophy, in accordance with it being part of the spectrum of multiple system atrophy.
对10例散发性橄榄脑桥小脑萎缩合并自主神经功能衰竭的患者进行了正电子发射断层扫描研究。受试者接受了[11C]二丙诺啡和[18F]氟多巴扫描。[11C]二丙诺啡的平均尾状核 - 枕叶摄取率显著降低至对照值的88%，壳核 - 枕叶摄取率降至对照值的85%。10例患者中有4例壳核中的阿片类药物结合显著降低。壳核[18F]氟多巴的平均摄取量显著减少（降至对照平均值的71%）；7例患者个体摄取量显著降低。[11C]二丙诺啡的壳核 - 枕叶摄取率与壳核[18F]氟多巴摄取之间存在显著正相关。我们的结果表明，大多数散发性橄榄脑桥小脑萎缩患者存在亚临床黑质纹状体功能障碍，这与它是多系统萎缩谱系的一部分相符。
