Ogren M, Hedblad B, Isacsson S O, Janzon L, Jungquist G, Lindell S E, Wollmer P
Department of Community Health Sciences, Lund University, Malmö General Hospital, Sweden.
Atherosclerosis. 1995 Feb;113(1):55-62. doi: 10.1016/0021-9150(94)05427-k.
A low pulse wave amplitude during calf plethysmography at 55 years of age was previously found to be associated with an increased mortality and incidence of myocardial infarction. In order to test the hypothesis that a low pulse wave amplitude is associated with an increased risk of future leg atherosclerosis as well, we have studied the relationship between a low ankle-brachial pressure index (ABPI; < 0.9) at 68 years of age and the pulse wave amplitude at 55 years of age in that same cohort. The prevalence of a low pulse wave amplitude (< or = 5 mm; lowest quintile) among men with a low ABPI (42%) was more than twice as high as it was among men who had a normal ABPI (19%) (P < 0.001). No association was found between a low ABPI and the plethysmographically recorded leg blood flow at 55 years of age. A low pulse wave amplitude might reflect early symptom-free arteriosclerosis, or age-dependent non-arteriosclerotic loss of vessel wall elasticity. The relationship between a low pulse wave amplitude and a low ABPI remained when controlling for smoking, hypertension and hyperlipidaemia. It is concluded that pulse wave measurement by plethysmography contributes information to improve leg atherosclerotic risk assessment in individuals exposed to known risk factors.
先前发现，55岁时小腿体积描记法检测的脉搏波振幅较低与死亡率增加及心肌梗死发病率增加有关。为了检验脉搏波振幅较低也与未来腿部动脉粥样硬化风险增加相关这一假设，我们研究了68岁时踝臂压力指数（ABPI；<0.9）较低与同一队列中55岁时脉搏波振幅之间的关系。ABPI较低的男性中脉搏波振幅较低（≤5mm；最低五分位数）的患病率（42%）是ABPI正常男性（19%）的两倍多（P<0.001）。未发现55岁时ABPI较低与体积描记法记录的腿部血流之间存在关联。较低的脉搏波振幅可能反映早期无症状的动脉硬化，或与年龄相关的非动脉硬化性血管壁弹性丧失。在控制吸烟、高血压和高脂血症后，较低的脉搏波振幅与较低的ABPI之间的关系依然存在。得出的结论是，通过体积描记法测量脉搏波有助于为评估已知风险因素个体的腿部动脉粥样硬化风险提供更多信息。
