Watling S M, Gehrke J C, Gehrke C W, Zumwalt R, Pribble J
Department of Pharmacy, University of Missouri, Columbia 65212, USA.
Am J Emerg Med. 1995 May;13(3):294-6. doi: 10.1016/0735-6757(95)90202-3.
Sodium polystyrene sulfonate, a cation exchange resin, should be useful in the treatment of lithium overdosage. This in vitro study was conducted to assess the ability of sodium polystyrene sulfonate to bind lithium, effects of pH on binding, binding efficacy in comparison to charcoal, and affinity for lithium versus potassium. Stock solutions of lithium were added to fixed amounts of sodium polystyrene sulfonate and charcoal. Lithium and potassium concentrations in supernatant were measured by flame photometry. Increasing concentrations of sodium polystyrene sulfonate bound more lithium. Changes in pH had little effect on lithium binding. Lithium is bound to sodium polystyrene sulfonate more readily than to charcoal. Potassium is preferentially bound to sodium polystyrene sulfonate over lithium. Sodium polystyrene sulfonate may provide a useful therapeutic modality in the treatment of lithium overdosage.
聚苯乙烯磺酸钠是一种阳离子交换树脂，在治疗锂过量方面应该会有用。进行这项体外研究是为了评估聚苯乙烯磺酸钠结合锂的能力、pH对结合的影响、与活性炭相比的结合效果以及对锂与钾的亲和力。将锂储备溶液添加到固定量的聚苯乙烯磺酸钠和活性炭中。通过火焰光度法测量上清液中的锂和钾浓度。聚苯乙烯磺酸钠浓度增加时结合的锂更多。pH的变化对锂的结合影响很小。锂与聚苯乙烯磺酸钠的结合比与活性炭的结合更容易。钾比锂更优先与聚苯乙烯磺酸钠结合。聚苯乙烯磺酸钠可能为治疗锂过量提供一种有用的治疗方式。
