Gehrke J C, Watling S M, Gehrke C W, Zumwalt R
Department of Surgery, University of Missouri, Columbia 65212, USA.
Am J Emerg Med. 1996 Jan;14(1):37-8. doi: 10.1016/S0735-6757(96)90010-8.
The purpose of this study was to determine if the exchange resin sodium polystyrene sulfonate increases the clearance of lithium in a healthy volunteer. A single healthy volunteer received 900 mg lithium for each of three study phases. A sodium polystyrene sulfonate dose of either 0, 20, or 40 grams was administered one half hour after each lithium dose to assess the effect on lithium clearance. Multiple blood samples were obtained for serum lithium concentrations over a 36- to 48-hour time period. Pharmacokinetic parameter estimates were calculated and compared. Sodium polystyrene sulfonate was found to increase the clearance of lithium in a single volunteer. Sodium polystyrene sulfonate may be useful in the treatment of lithium intoxication by increasing the clearance of lithium.
本研究的目的是确定交换树脂聚苯乙烯磺酸钠是否能增加健康志愿者体内锂的清除率。一名健康志愿者在三个研究阶段中，每个阶段均接受900毫克锂。在每次锂剂量给药半小时后，分别给予0、20或40克聚苯乙烯磺酸钠剂量，以评估对锂清除率的影响。在36至48小时的时间段内采集多份血样以测定血清锂浓度。计算并比较药代动力学参数估计值。结果发现聚苯乙烯磺酸钠可增加一名志愿者体内锂的清除率。聚苯乙烯磺酸钠可能通过增加锂的清除率而有助于锂中毒的治疗。
